The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Application:
FC
Recommended Usage:
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 20 µl per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
CXCR7 transfected mouse L1.2 cells stained with 8F11-M16 PE
Description:
CXCR7 belongs to a subgroup of C-X-C chemokine receptors, also known as G protein-coupled receptors (GPCR), or RDC1.CXCR7 can bind with high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC, which regulates the trafficking and activation of leukocytes. It is also a co-receptor in the entry of HIV-1 and proliferation and migration of immature neurons, glia and their precursors.CXCR7 occurs on a wide variety of tissues and cells including monocytes, B cells, T cells and mature dendritic cells.But surface expression of CXCR7 was reported to be restricted to tumor cells, activated endothelial cells, fetal liver cells, and few other cell types. It is not fully understood to these inconsistent observations yet.
