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The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 µl to 5 µl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 µl staining volume or per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
COA:
Application Notes:
Additional reported (for the relevant formats) applications include: trigger ILT7 mediated signaling.The LEAF™ purified antibody (Endotoxin <0.1 EU/μg, Azide-Free, 0.2 μm sterile-filtered) is recommended for functional assays (Cat. No. 326404).
CD14- human peripheral blood mononuclear cells stained with CD123 APC and 17G10.2 PE
ILT7 (immunoglobulin-like transcript 7) is a member of leukocyte immunoglobulin-like receptor (LIR or LILR) gene family, also known as CD85g and LILRA4. It contains four extracellular Ig domains. In association with FcεR1γ, ILT7 forms a receptor complex that transduces ITAM-mediated signals. ILT7 is specifically expressed on plasmacytoid dendritic cells (pDCs), but not on myeloid dendritic cells and other peripheral blood leukocytes. ILT7 negatively regulates the innate immune functions of human pDCs. Cross-linking 17G10.2 antibody is able to trigger ILT7 mediated signaling.
Other Names:
CD85g, immunoglobulin-like transcript 7, LILRA4
Structure:
Associate with FcεR1γ leukocyte immunoglobulin-like receptor gene family
Distribution:
Plasmacytoid dendritic cells
Function:
Negatively regulates pDC mediated innate immune function
Antigen References:
1. Cao W, et al. 2006. J. Exp. Med. 203(6):1399. 2. Brown D, et al. 2004. Tissue Antigen. 64:215. 3. Rissoan MC, et al. 2002. Blood 100:3295.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Biotin anti-human CD85g (ILT7)
Human peripheral blood mononuclear cells stained with CD123 (6H6) APC and biotinylated mouse IgG1 isotype control, followed by Sav-PE (gated on lymphocyte population)
Human peripheral blood mononuclear cells stained with CD123 (6H6) APC and biotinylated 17G10.2, followed by Sav-PE (gated on lymphocyte population)
PE anti-human CD85g (ILT7)
CD14- human peripheral blood mononuclear cells stained with CD123 APC and 17G10.2 PE
Alexa Fluor® 647 anti-human CD85g (ILT7)
Human peripheral blood mononuclear cells stained with CD123 PE and 17G10.2 Alexa Fluor® 647
