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The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 µl to 5 µl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 µl staining volume or per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
COA:
Application References:
1. Bouchon A, et al. 2001. J. Immunol. 167:551721. 2. Tassi I and Colonna M. 2005. J. Immunol. 175:79968002. 3. Veillette A. 2006. Immunol. Rev. 214:2234.
Human peripheral blood lymphocytes stained with CD3 (HIT3a) APC and 162.1 PE
CD319 is a single-pass type-1 335 aa transmembrane glycoprotein and expressed on NK cells, subsets of mature dendritic cells, activated B cells, cytotoxic lymphocytes but not in promyelocytic, B- or T-cell lines. Expression is high in spleen, lymph node, periperal blood leukocytes and lowest in bone marrow. Expression is in small intestine, stomach, appendix, lung and trachea. CD319 is tyrosine phosphorylated in activated NK cells and is associated with 19- and 39 kD proteins. CD319 has a homology with the CD2 family of receptors within the Ig superfamily. Some of the CD2 members stimulate cytotoxicity through the CD319 associated protein.
Other Names:
SLAMF7 (SLAM family member 7), CRACC (CD2 like receptor for activating cytotoxic cells), 19A24, 19A, CS1
Structure:
Ig superfamily, 66kD
Distribution:
NK cells, subsets of mature dendritic cells, activated B cells, cytotoxic lymphocytes but not in promyelocytic, B- or T-cell lines
Function:
regulating T cell and NK cell functions
Antigen References:
1. Bouchon A, et al. 2001. J. Immunol. 167:551721. 2. Tassi I and Colonna M. 2005. J. Immunol. 175:79968002. 3. Veillette A. 2006. Immunol. Rev. 214:2234.
PE anti-human CD319 (CRACC), 162.1, PE, SLAMF7 (SLAM family member 7), CRACC (CD2 like receptor for activating cytotoxic cells), 19A24, 19A, CS1, Human, Immunology, Antibodies
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human CD319 (CRACC)
Human peripheral blood lymphocytes stained with purified 162.1, followed by anti-mouse IgG FITC
PE anti-human CD319 (CRACC)
Human peripheral blood lymphocytes stained with CD3 (HIT3a) APC and 162.1 PE
