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PE anti-human CD209 (DC-SIGN) Antibody
PE anti-human CD209 (DC-SIGN) Antibody
343003 25 tests $135.00     
343004 100 tests $280.00     
Product Details
Clone: DCS-8C1
Isotype: Mouse IgG2b, κ
Isotype Control:PE Mouse IgG2b, κ Isotype Ctrl
Reactivity: Human, Cross-Reactivity*: Macaque
Immunogen: Extracellular domain of human DC-SIGN
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Storage & Handling: The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 µl to 5 µl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 µl staining volume or per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
COA:
Enter Lot#:   
 Human monocyte-derived dendritic cells stained
Human monocyte-derived dendritic cells stained with DCS-8C1 PE


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Description:

CD209, known as Dendritic Cell-Specific Intercellular adhesion molecule 3 (ICAM-3)-Grabbing Nonintegrin (DC-SIGN), is a 44 kD type II transmembrane glycoprotein and a member of the C-type lectin family. CD209 is expressed on myeloid dendritic cells, placental macrophages, liver and placental endothelial cells. CD209 binds to ICAM-3 (CD50), ICAM-2 (CD102), and Butyrophilin (BTN2A1), and mediates dendritic cell migration and T cell proliferation. Importantly, CD209 is a receptor of HIV-1 and some other viruses (such as West Nile virus, hepatitis C virus, etc), and some bacteria or parasites. It plays a criti­cal role in capturing and internalizing those pathogens. LSP1 (leukocyte-specific protein 1) interacts with the cytoplasmic domain of CD209 and mediates transport of HIV to the proteasome.
Other Names: Dendritic Cell-Specific Intercellular adhesion molecule 3 (ICAM-3)-Grabbing Nonintegrin
Distribution: Dendritic cells
Antigen
References:

1. Granelli-Piperno A, et al. 2005. J Immunol. 175:4265.
GeneID: 30835
Latest Publications: View the latest CD209 articles on HighwirePress.com
UniProt: View information about CD209 on UniProt.org
Keywords: PE anti-human CD209 (DC-SIGN), DCS-8C1, PE, Dendritic Cell-Specific Intercellular adhesion molecule 3 (ICAM-3)-Grabbing Nonintegrin, Human, Cross-Reactivity*: Macaque, Immunology, Antibodies
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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
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Compare Data Across All Formats
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
  • Purified anti-human CD209 (DC-SIGN)
    Human monocyte-derived dendritic cells stained

    Human monocyte-derived dendritic cells stained with DCS-8C1 PE

  • PE anti-human CD209 (DC-SIGN)
    Human monocyte-derived dendritic cells stained

    Human monocyte-derived dendritic cells stained with DCS-8C1 PE

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