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The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 µl to 5 µl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 µl staining volume or per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
COA:
Human peripheral blood lymphocytes were stained with CD3 APC and CXCR3 (clone G025H7) PE (top plot) or mouse IgG1 PE isotype control (bottom plot).
Human CXCR3, also known as GPR9, is a chemokine receptor that binds CXCL9, CXCL10, and CXCL11. It is a 38 kD seven-pass transmembrane receptor coupled to G-protein. CXCR3 is highly expressed by T lymphocytes (Th1), natural killer cells (NK cells), dendritic cells, mast cells, alveolar macrophages, eosinophils, and human airway epithelial cells. CXCR3 is important for effector lymphocyte recruitment into inflamed tissue in various inflammatory and autoimmune diseases, such as chronically inflamed human liver, Crohn's disease, rheumatoid arthritis, multiple sclerosis, and inflammatory skin diseases.
CXC-chemokine receptor, G protein-coupled receptor, seven-pass transmembrane receptor
Distribution:
T subset, NK cells, plasmacytoid dendritic cells, GM-CSF activated CD34 (+) hematopoietic progenitors, mast cells, alveolar macrophages, eosinophils, and human airway epithelial cells
Function:
Essential in T cell recruitment to sites of inflammation
Ligand Receptor:
CXCL9, CXCL10, and CXCL11
Antigen References:
1. Loetscher M, et al. 1996. J. Exp. Med. 184:963. 2. Cole KE, et al. 1998. J. Exp. Med. 187:2009. 3. Aksoy MO, et al. 2006. Am. J. Physiol. Lung Cell Mol. Physiol. 290:L909. 4. Curbishley SM, et al. 2005. Am. J. Pathol. 167:887. 5. Turner JE, et al. 2007. Mini. Rev. Med. Chem. 7:1089. 6. Wenzel J, et al. 2008. J. Invest. Dermatol. 128:67.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human CD183 (CXCR3)
Human peripheral lymphocytes were stained with purified anti-human CXCR3 (clone G025H7) (filled histogram) or mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG FITC.
FITC anti-human CD183 (CXCR3)
Human peripheral lymphocytes were stained with CD3 PE and CXCR3 (clone G025H7) FITC (top) or mouse IgG1, κ FITC isotype control (bottom).
PE anti-human CD183 (CXCR3)
Human peripheral blood lymphocytes were stained with CD3 APC and CXCR3 (clone G025H7) PE (top plot) or mouse IgG1 PE isotype control (bottom plot).
APC anti-human CD183 (CXCR3)
Human peripheral lymphocytes were stained with CD3 FITC and CXCR3 (clone G025H7) APC (top) or mouse IgG1, κ APC isotype control (bottom).
Alexa Fluor® 488 anti-human CD183 (CXCR3)
Human peripheral blood lymphocytes were stained with CD3 APC and CXCR3 (clone G025H7) Alexa Fluor® 488 (top) or mouse IgG1 Alexa Fluor® 488 isotype control (bottom).
Alexa Fluor® 647 anti-human CD183 (CXCR3)
Human peripheral blood lymphocytes were stained with CD3 PE and CXCR3 (G025H7) Alexa Fluor® 647 (top) or mouse IgG1 Alexa Fluor® 647 isotype control (bottom).
PerCP/Cy5.5 anti-human CD183 (CXCR3)
Human peripheral lymphocytes were stained with CD3 FITC and CXCR3 (clone G025H7) PerCP/Cy5.5 (top) or mouse IgG1, κ PerCP/Cy5.5 isotype control (bottom).
Brilliant Violet 421™ anti-human CD183 (CXCR3)
Human peripheral blood lymphocytes were stained with CD3 FITC and CXCR3 (clone G025H7) Brilliant Violet 421™ (top) or mouse IgG1, κ Brilliant Violet 421™ isotype control (bottom).
LEAF™ Purified anti-human CD183 (CXCR3)
Anti-human CXCR3 (G025H7) blocks the chemotaxis of Baf3-hCXCR3 transfectants.
