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Natural Killer (NK) cells were initially named based on the observation that they had cytolytic function in the absence of any specific kind of immunization. NK cells can release a bounty of cytokines and chemokines, including TNF-α
, XCL1, and CXCL8
. Type I IFNs, IL-2
, and IL-18
are all potent activators of NK cells. NK cells are a vital arm of innate immunity and participate in surveillance against viral-infection and tumor cells.View our: Innate Immunity Pathways
Originating from the thymus, NKT (Natural Killer T) cells represent a combination of T cell and NK cell attributes/markers. They express a T cell receptor (TCR) complex and several NK cell markers. The ability of these cells to produce Th1 and Th2-related cytokines has implicated them in several fields, including transplantation, tumors, autoimmunity, and allergy.View our: Innate Immunity Pathways
NK and NKT cells are ready to fight.