Human IL-17A/F is a heterodimeric member of the IL-17 family It is a pro-inflammatory cytokine secreted by activated Th17 cells in response to bacteria and fungi. There is great interest in IL-17 family members, not only for their role in adaptive immunity and inflammation, but also in a variety of auto-immune diseases, such as Crohn's disease, ulcerative colitis, psoriasis, multiple sclerosis, rheumatoid arthritis, asthma, and lupus.
IL-17A/F consists of the monomeric units of IL-17A and IL-17F, which share 50% amino acid sequence identity. It has been shown to be a naturally expressed and biologically active molecule. While much has been studied about IL-17A and IL-17F, it is still unclear how each distinctively induces the inflammatory response, and what role IL-17A/F also plays in it. It is known that all three cytokines are produced in different amounts, and each has different degrees of pro-inflammatory effects. All seem to interact with the IL-17RA/IL-17RC receptor complex, and signal via the NF-κB pathway to induce secretion of inflammatory cytokines and recruit granulocytes.
BioLegend's LEGEND MAX™ Human IL-17A/F ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (ELISA), in which, a specific antibody is pre-coated on a 96-well strip-well plate.
BioLegend's LEGEND MAX™ Human IL-17A/F ELISA Kit is specifically designed for the accurate quantitation of Human IL-17A/F from cell culture supernatant, serum, plasma or other bodily fluids. It is ready-to-use, accurate, and sensitive.