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Purified anti-human Delta-like protein 4 (DLL4) Antibody
Purified anti-human Delta-like protein 4 (DLL4) Antibody
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
Additional reported applications for the relevant formats include: blocking DLL4 binding to Notch1 and Notch4
Application References:
1. Yamanda S, et al. 2009. Blood 113:3631
Human DLL4 transfected CHO cells stained with MHD4-46 PE
Delta-like protein 4 is a t type I transmembrane protein which extracellular domain which contains a DSL domain and eight tandem EGF repeats. After binding of its ligands Notch-1 and Notch-4, the extracellular and cytoplasmic domains are cleavage and the cytoplasmic domain is translocated into the cell nucleus. Delta-like protein 4 is expressed in the vascular endothelium, neural epithelium, adrenal cortex, spleen, and lymph nodes, also is highly expressed in some types of bladder, breast and renal carcinomas. Function as a critical for the vascular development and homeostasis.
Other Names:
DLL4, Delta4, Drosophila Delta homolog 4, DLL
Structure:
Type I transmembrane protein which extracellular domain which contains a DSL domain and eight tandem EGF repeats. The cytoplasmic domains occur and the later is translocated into the cell nucleus.
Distribution:
Vascular endothelium, neural epithelium, adrenal cortex, spleen, and lymph nodes. Highly expressed in some types of bladder, breast and renal carcinomas.
Function:
Vascular development and homeostasis
Ligand Receptor:
Notch-1 and Notch-4
Antigen References:
1. Beck RC et al. 2009. Biol Blood Marrow Transplant. 15:1026 2. Mazella J et al. 2008. Endocrinology. 149:15 3. Noguera-Troise I et al. 2006. Nature 444:1032 4. Sugimoto A et al. 2006. Exp Hematol. 34:424 5. Liu ZJ et al. 2003. Mol Cell Biol. 23:14
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Purified anti-human Delta-like protein 4 (DLL4)
Human DLL4 transfected CHO cells stained with MHD4-46 PE
PE anti-human Delta-like protein 4 (DLL4)
Human DLL4 transfected CHO cells stained with MHD4-46 PE
