Innate Immune Signaling: Pattern Recognition Receptors

Infection or tissue injury causes innate immune cells such as Dendritic cells, Macrophages, and Neutrophils, to recognize pathogen-associated molecular patterns (PAMPs) or host derived damage-associated molcular patterns (DAMPs) via pattern recognition receptors (PRRs) on the cell surface and in the cytoplasm. The major PRRs on cells include Toll-Like receptors (TLRs), NOD-like receptors (NLRs), and retinoic acid-inducible gene 1 (RIG-I) like receptors (RLRs). BioLegend offers variety of reagents to study these pathways for innate immune cell signaling.

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