Human Cell Adhesion Molecules

Mouse Cell Adhesion Molecules.

Interactive Human CD Molecule chart

Interactive Mouse CD Molecule chart

1. β1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Martina Bauer, Cord Brakebusch, Caroline Coisne, Michael Sixt, Hartmut Wekerle, Britta Engelhardt, and Reinhard Fässler. PNAS. Feb 2009; 106: 1920 - 1925. PubMed

2. Ambient Air Pollution Exaggerates Adipose Inflammation and Insulin Resistance in a Mouse Model of Diet-Induced Obesity. Qinghua Sun, Peibin Yue, Jeffrey A. Deiuliis, Carey N. Lumeng, Thomas Kampfrath, Michael B. Mikolaj, Ying Cai, Michael C. Ostrowski, Bo Lu, Sampath Parthasarathy, Robert D. Brook, Susan D. Moffatt-Bruce, Lung Chi Chen, and Sanjay Rajagopalan. Circulation. Feb 2009; 119: 538 - 546. PubMed

3. Surfactant protein-A modulates cell surface expression of CR3 on alveolar macrophages and enhances CR3-mediated phagocytosis. Malgorzata Gil, Francis X. McCormack, and Ann Marie LeVine. J. Biol. Chem. Jan 2009; 10.1074/jbc.M808643200. PubMed

4. NKp80 defines and stimulates a reactive subset of CD8 T cells. Sabrina Kuttruff, Sven Koch, Alexandra Kelp, Graham Pawelec, Hans-Georg Rammensee, and Alexander Steinle. Blood. Jan 2009; 113: 358 - 369. PubMed

5. The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace. Zhuowei Li, Stavros Garantziotis, Wei Jia, Erin N. Potts, Sikander Lalani, Zhi Liu, You-Wen He, W. Michael Foster, and John W. Hollingsworth. J. Leukoc. Biol. Jan 2009; 85: 124 - 131. PubMed

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The 9C4 monoclonal antibody recognizes human CD326 also known as Ep-CAM, tumor associated calcium signal transducer 1, epithelial cell surface antigen, epithelial glycoprotein 2, EGP2, adenocarcinoma associated antigen, and TROP1. CD326 is a type I transmembrane protein containing six disulfide bridges, and one THYRO domain. This cell surface, glycosyl;ated 40kD protein is highly expressed in the bone marrow, colon, lung, and most normal epithelial cells and is expressed on carcinomas of gastrointestinal origin. Recently, it has been reported that CD326 expression occurs during the early steps of erythrogenesis. CD326 functions as a homotypic calcium-independent cell adhesion molecule and is believed to be involved in carcinogenesis by its ability to induce genes involved in cellular metabolism and proliferation. The CD326 antigen is an immunotherapeutic target for the treatment of human carcinomas. The 9C4 antibody has been shown to be useful for flow cytometry.

β-catenin is a 94 kD nuclear and cytoplasmic protein containing Armadillo repeats. This protein is involved in cell-cell adhesion, wingless/WNT signaling pathway, and has been implicated as an oncogene. β-catenin can be modified by glycosylation, phosphorylation, and ubiquitination to target for degradation. This protein has been shown to interact with E-cadherin, α-catenin, axin, APC, GSK-3β, and Tcf/Lef. Dissociation from axin allows cytoplasmic accumulation, after nuclear translocation binds Tcf/Lef. The Poly6001 antibody has been reported to be useful for Western blotting and immunofluorescence of the mouse and human β-catenin protein.

CD29 is a 130 kD protein, also known as integrin β1, VLA-β chain, or GPIIa. It is a member of the integrin family, expressed broadly on leukocytes, endothelial cells, smooth muscle, and epithelial cells. In association with CD49a-f, CD29 forms the VLA-1 through VLA-6 complexes, respectively. It plays an important role in cell-cell or cell-matrix interaction. The HMβ1-1 antibody reacts with both mouse and rat CD29. It is able to block cell adhesion and inhibit T cell proliferation.

CD54 is also known as ICAM-1 and Ly-47. It is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, and inhibits cell-cell adhesion, antigen presentation to T cells, and leukocyte migration to inflammatory tissues.

CD84 is a 64-82 kD glycoprotein. It is a member of the SLAM (CD150) family, a CD2 subset of the Ig superfamily, also known as SLAMF5 or Ly9b. CD84 is expressed on B cells, monocytes, thymocytes, subset of T cells, and platelets. CD84 functions as a homophilic adhesion molecule and enhances T cell activation and cytokine production.

p130 Cas (Crk-associated substrate) is a 120-130 kD docking protein and a central coordinator for tyrosine-kinase-based signaling related to cell adhesion. p130 Cas has been implicated in induction of cell migration, growth factor stimulation, cytokine receptor engagement, cardiovascular development, and actin filament assembly. p130 Cas is localized to focal adhesions and stress fibers. The Poly6139 antibody recognizes the C-terminal region of human p130 Cas and has been shown to be useful for Western blotting.

Galectin 3 (also known as galactose-specific lectin 3 and Mac-2 antigen) is a 32 kD member of the galaptin (S-lectin) family, BH-1, that contains carbohydrate recognition domains. Galectin 3 has been shown to modulate allergic reactions and regulate mRNA splicing activity, cell cycle control, and cell adhesion. Galectin 3 has been shown to interact with IgE, galactose, casein kinase I, laminin, mucin, β-galactoside residues of cell surface, matrix glycoproteins, and some intracellular proteins. The Poly6132 antibody recognizes human and mouse galectin 3 and has been shown to be useful for Western blotting.