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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
Additional reported applications (for the relevant formats) include: immunohistochemistry of acetone-fixed frozen sections1, and Western blotting.
Application References:
1. Matsuura A, et al. 1984. J. Immunol. 132:316. (IHC)
Description:
CD5, a 67 kD glycoprotein, is a member of the scavenger receptor superfamily. It is expressed on thymocytes, T cells, and a subset of B cells. CD5 has been reported to associate with the T cell receptor, the B cell receptor and many accessory proteins (CD21, CD4, CD8). In some cases, CD5 can augment signaling, while in other cases it appears to confer an inhibitory signal (depending on the cell type and the differentiation state).
Other Names:
Ly-1, Tp67, T1, Leu-1
Structure:
Scavenger receptor superfamily, approximately 67 kD
Distribution:
Thymocytes, T cells, B cell subset
Function:
Modulates T and B cell receptor signaling; may act as dual receptor providing stimulatory or inhibitory signal depending on cell type and developmental stage
Interaction:
TCR, CD3, CD2, CD4, CD8, CD21, BCR
Antigen References:
1. Ishii Y, et al. 1983. Immunol. 48:743. 2. Matsuura A, et al. 1984. J. Immunol. 132:316. 3. Ibayashi Y, et al. 1985. J. Immunol. 134:648. 4. Martin A, et al. 1996. Thymus 24(2):111.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
