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FITC anti-mouse TCR γ/δ Antibody
FITC anti-mouse TCR γ/δ Antibody
107503 50 µg $75.00 Qty:
    
107504 500 µg $250.00 Qty:
    

Product Details

 
Clone: UC7-13D5 (See other available formats)
Isotype: Armenian Hamster IgG
Isotype Control:FITC Armenian Hamster IgG Isotype Ctrl
Reactivity: Mouse
Formulation: Tris-buffered solution pH 8.0, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation
Laser:
Blue Laser (488 nm)
COA:
Enter Lot#:   
Application
Notes:

Additional reported applications (for the relevant formats) include: immunoprecipitation1, in vitro stimulation1,2,4 and in vivo depletion3-5. The LEAF™ purified antibody (Endotoxin <0.1 EU/μg, Azide-Free, 0.2 μm filtered) is recommended for functional assays (Cat. No. 107506).

Application
References:

  Publication Library
FITC anti-mouse TCR γ/δ Antibody UC7-13D5 Image 1
C57BL/6 splenocytes stained with CD3 (145-2C11) APC and UC7-13D5 FITC


Compare all formats

See FITC spectral data



Cell Surface Immunofluorescence Staining Protocol




Description:

T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ belongs to the immunoglobulin superfamily, involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. The TCR γ/δ associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8-, some are CD8+. T cells expressing the TCR γ/δ have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation. Immobilized UC7-13D5 antibody has been reported to activate TCR-γ/δ-bearing T cells in vitro, and to deplete peripheral TCR-γ/δ-bearing T cells in vivo.

  Learn more about TCR γ/δ nomenclature.

Other Names: TCR-γ/δ, γ/δ TCR
Structure: Ig superfamily, associates with CD3 complex
Distribution: T subset in thymus, intestinal epithelium, peripheral lymphoid tissues and peritoneum
Function: Antigen recognition
Ligand Receptor: Some bacterial or tumor antigens bound MHC class I
Antigen
References:

1. Skarstein K, et al. 1995. Immunology 81:497.
2. Harrison LC, et al. 1996. J. Exp. Med. 184:2167.
3. Wildner G, et al. 1996. Eur. J. Immunol. 26:2140.
4. Brandes M, et al. 2005. Science 309:264.

GeneID: 110066
110067
Latest Publications: View the latest TCR gamma/delta articles on HighwirePress.com
UniProt: View information about TCR gamma/delta on UniProt.org
Keywords: FITC anti-mouse TCR γ/δ, UC7-13D5, FITC, TCR-γ/δ, γ/δ TCR, Mouse, Flow Cytometry, Immunology, Antibodies


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DescriptionCloneApplications
FITC anti-mouse CD3ε145-2C11FC
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FITC Armenian Hamster IgG Isotype CtrlHTK888FC, ICFC
TruStain fcX™ (anti-mouse CD16/32)93 FC


Other Formats

DescriptionCloneApplications
Alexa Fluor® 488 anti-mouse TCR γ/δUC7-13D5FC
LEAF™ Purified anti-mouse TCR γ/δ UC7-13D5Costim, Depletion, FC, IP
PE anti-mouse TCR γ/δUC7-13D5FC
Purified anti-mouse TCR γ/δUC7-13D5FC, IP


Related Pathways

Pathway
Cancer Immunoediting
CD4 and CD8 T-Cell Lineage
Gamma-Delta T cells
Th17 Biology


Related Categories

Category
Immunology > Mouse Immunology > Innate Immunity > T Cell Receptors
Immunology > Mouse Immunology > T Regulatory Cells (TReg) > T Cell Receptors
Immunology > Mouse Immunology > T Cell Receptors (TCRs) > TCR γ/δ
Immunology > Mouse Immunology > T Cell Receptors (TCRs) > TCR γ/δ > UC7-13D5
Immunology > Mouse Immunology > Adhesion Molecules > TCR γ/δ > UC7-13D5
Immunology > Mouse Immunology > Th17 > γ/δ TCR > UC7-13D5
Immunology > Mouse Immunology > Costimulatory Molecules > γ/δ TCR > UC7-13D5
Immunology > Mouse Immunology > CD and Related Molecules > TCR γ/δ > UC7-13D5

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

Version: 2 Revision Date: 2013-11-19
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Compare Data Across All Formats
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.

  • FITC anti-mouse TCR γ/δ
    C57BL/6 splenocytes stained with CD3

    C57BL/6 splenocytes stained with CD3 (145-2C11) APC and UC7-13D5 FITC

  • Purified anti-mouse TCR γ/δ
    C57BL/6 splenocytes stained with 17A2

    C57BL/6 splenocytes stained with 17A2 (CD3) APC and purified UC7-13D5, followed by anti-Armenian hamster IgG PE

  • PE anti-mouse TCR γ/δ
    C57BL/6 mouse lymph node cells

    C57BL/6 mouse lymph node cells stained with 145-2C11 APC and UC7-13D5 PE

  • Alexa Fluor® 488 anti-mouse TCR γ/δ
    C57BL/6 mouse splenocytes stained with

    C57BL/6 mouse splenocytes stained with CD3 (17A2) PE and UC7-13D5 Alexa Fluor® 488

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