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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application References:
1. Vance RE, et al. 1999. J. Exp. Med. 190:1801. 2. Tang X, et al. 2006. J. Immunol. 177:7645. This product may be used for research purposes only. It is not licensed for resale and may only be used by the buyer. This product may not be used and is not licensed for clinical assays where the results of such assays are provided as a diagnostic service. If a diagnostic or therapeutic use is anticipated then a license must be requested from the University of California. The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.
C57BL/6 mouse splenocytes stained with 18d3 FITC and DX5 PE
CD94 is a 43/39 kD C-type lectin, also known as Kp43. It is present on all NK cells, NK-T cells, and a subset of CD8-positive T lymphocytes in most mouse strains. CD94 is a type-II transmembrane protein with an extracellular lectin-like domain and a short cytoplasmic tail. CD94 is expressed as a disulphide-linked heterodimer with a NKG2 subunit believed to mediate signal transduction. When associated with NKG2A, the complex triggers inhibition; when associated with NKG2C, the complex triggers stimulation. The receptor complex of CD94 and NKG2 receptors bind to the ligand, Qa-1, and are thought to play a role in maintaining self-tolerance in developing NK cells.
Other Names:
Kp43
Structure:
C-type lectin; 43/39 kD
Distribution:
NK cells, NK-T cells, CD8+ T subset
Function:
Inhibits NK cell function
Ligand Receptor:
CD94/NKG2
Antigen References:
1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Lopez-Botet M, et al. 1997. Immunol. Rev. 155:165. 3. Moretta A, et al. 1997. Immunol. Rev. 155:105. 4. Phillips JH, et al. 1996. Immunity 5:163.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
FITC anti-mouse CD94
C57BL/6 mouse splenocytes stained with 18d3 FITC and DX5 PE
PE anti-mouse CD94
C57BL/6 splenocytes stained with 18d3 PE and DX5 FITC
Purified anti-mouse CD94
C57BL/6 splenocytes stained with 18d3 PE and DX5 FITC
