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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 µl to 5 µl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 µl staining volume or per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
COA:
Application Notes:
Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections and blocking of platelet aggregation2. The HIP8 antibody has been reported to block the activation of platelets by various stimuli, including collagen, and ADP.
Application References:
1. Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York. 2. McCarty OJT, et al. 2000. Blood 96:1789. 3. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
Human peripheral blood platelets stained with HIP8 FITC
CD41 is a 125/25 kD α subunit of the gpIIb/IIIa (CD41/CD61) complex. CD41 is a heterodimer composed of a heavy chain (gpIIbα) and light chain (gpIIbβ) linked by a single disulfide bond. It is a member of the integrin family primarily expressed on platelets and megakaryocytes. CD41 has been reported to be involved with platelet aggregation and platelet attachment to the ECM. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, and thrombin.
Other Names:
gpIIb
Structure:
Integrin family, α subunit of CD41/CD61 (GPIIb-IIIa) complex, 125/22 kD
Distribution:
Platelets, megakaryocytes
Function:
Platelet aggregation, platelet attachment to extracellular matrix
Ligand Receptor:
Fibrinogen, fibronectin, von Willebrand factor, thrombin
Antigen References:
1. Denzin L, et al. 1996. J. Exp. Med. 184:2153. 2. Denzin L, et al. 1995. Cell 82:155. 3. Riberdy J, et al. 1994. J. Cell Biol. 125:1225.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
APC anti-human CD41
Human platelets stained with
HIP8 PE
FITC anti-human CD41
Human peripheral blood platelets stained with HIP8 FITC
PE anti-human CD41
Human platelets stained with
HIP8 PE
PE/Cy5 anti-human CD41
Human peripheral blood platelets stained with HIP8 PE/Cy5
Purified anti-human CD41
Human peripheral blood platelets stained with HIP8, followed by anti-mouse IgGs FITC
LEAF™ Purified anti-human CD41
Human peripheral blood platelets stained with LEAF™ purified HIP8, followed by anti-mouse IgG FITC
Pacific Blue™ anti-human CD41
Human peripheral blood platelets were stained with CD41 (clone HIP8) Pacific Blue™ (filled histogram) or mouse IgG1, κ Pacific Blue™ isotype control (open histogram).
APC/Cy7 anti-human CD41
Human platelets were stained with CD41 (clone HIP8) APC/Cy7 (filled histogram) or mouse IgG1 APC/Cy7 isotype control (open histogram).
PE/Cy7 anti-human CD41
Human platelets were stained with CD41 (clone HIP8) APC/Cy7 (filled histogram) or mouse IgG1 APC/Cy7 isotype control (open histogram).
