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Biotin anti-mouse Tim-2 Antibody
Biotin anti-mouse Tim-2 Antibody
119604 500 µg $350.00     
Product Details
Clone: RMT2-1
Isotype: Rat IgG2a, κ
Isotype Control:Biotin Rat IgG2a, κ Isotype Ctrl
Reactivity: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted at 4°C. Do not freeze.
Application:

FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance in each application.
COA:
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Application
References: 		1. Nakae S, et al. 2007. Blood doi:10.1182/blood-2006-11-058800.
Mouse Tim-2 transfected cells stained
Mouse Tim-2 transfected cells stained with biotinylated RMT2-1, followed by Sav-PE


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Description: Tim-2 is a transmembrane protein known as T cell immunoglobulin and mucin domain containing protein-2. It is expressed on activated T cells and preferentially on differentiated Th2 cells. Sema4A is the ligand of Tim-2. A blockade of Tim-2/Tim-2 ligand interaction results in T cell hyperproliferation and Th2 cytokine production. Tim-2 plays a critical role in the development of atopic disease and other Th2-biased immune responses.
Other Names: T cell immunoglobulin and mucin domain containing protein-2
Structure: Transmembrane protein containing immunoglobulin domain and mucin-like domain; predicted molecular weight 33 kD
Distribution: Developmentally regulated; highly expressed in embryonic development at the 8-cell stage and blastocyst. Expressed on activated T lymphocytes.
Function: Plays a critical role in immune responses and the development of atopic diseases
Ligand Receptor: Binds to Sema4A
Antigen
References: 		1. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454.
2. Kumanogoh A, et al. 2002. Nature 419:629.
3. Chakravarti S, et al. 2005. J. Exp. Med. 202:437.
GeneID: 171284
Latest Publications: View the latest Tim-2 articles on HighwirePress.com
UniProt: View information about Tim-2 on UniProt.org
Keywords: Biotin anti-mouse Tim-2, RMT2-1, Biotin, T cell immunoglobulin and mucin domain containing protein-2, Mouse, Immunology, Antibodies
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
  • Biotin anti-mouse Tim-2
    Mouse Tim-2 transfected cells stained

    Mouse Tim-2 transfected cells stained with biotinylated RMT2-1, followed by Sav-PE

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