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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Human retinoblastoma cell line, Weri-RB-1 cells, stained with biotinylated W3C4E11, followed by Sav-PE
CD349 is a member of the Frizzled family, known as Frizzled-9 (Fz9, FZD9, hFz9, or FzE6) which was originally described as FZD3. Ten frizzled member have been identified in humans. FZD9 is a seven transmembrane G-protein-coupled receptor (GPCR), a receptor for Wnt proteins. It is involved in the activation of Wnt/β-catenin pathway (canonic Wnt signaling). FZD9 is predominately expressed in fetal and adult brain, testis, eye, skeletal muscle and kidney and is also expressed on Mesenchymal stem cells, and neural precursor cells. Frizzled proteins play important roles in controlling cell fate, proliferation, migration, tissue architecture and organogenesis during embryonic development and in adult organisms. FZD9 is an important factor for nervous system development and is critical for hippocampal development.
adult and fetal brain, testis, eye, skeletal muscle and kidney, mesenchymal stem cells, neural precursor cells
Function:
Activation of Wnt/b-catenin pathway, regulate tissue and cell polarity, embryonic development, especially for nervous system development
Ligand Receptor:
Wnt proteins
Antigen References:
1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley & Sons Inc, Publication 2. Battula VL, et al. 2007. Differentiation 75:279. 3. Botta A, et al. 1999. J. Med. Genet. 36:478.
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human CD349 (Frizzled-9)
Human retinoblastoma cell line Weri-RB cells stained purified W3C4, followed by biotinylated anti-mouse IgG and Sav-PE
Biotin anti-human CD349 (Frizzled-9)
Human retinoblastoma cell line, Weri-RB-1 cells, stained with biotinylated W3C4E11, followed by Sav-PE
Alexa Fluor® 647 anti-human CD349 (Frizzled-9)
Human retinoblastoma cell line, Weri-RB-1 cells, stained with W3C4E11 Alexa Fluor® 647
