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The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Concentration:
0.2 mg/ml
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
3.2.3 recognizes a common epitope of NKR-1P1a (CD161a) and NKR-P1b (CD161b).
Application References:
1. Chambers W, et al. 1989. J. Exp. Med. 169:1373. (FC)
Lewis rat splenocytes were stained with CD161 (clone 3.2.3) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
CD161 is a 30 kD type II transmembrane C-type lectin, expressed as a homodimer. Rat NKR-P1 receptors are primarily expressed on NK cells, a subset of T cells, dendritic cells, and activated monocytes. There are three different types of NKR-P in rat, namely NKR-P1a, KNR-P1b and NKR-P1c. NKR-P1a does not contain an ITIM structure and is an activating receptor, while NKR-P1b contains an ITIM and displays inhibitory function. LLT-1 (ligand lectin like transcript 1) is the ligand, while KLR (killer cell lectin like) functions as a receptor.
Other Names:
NKR-P1, CD161a/CD161b, NKR-P1a/KLRB1a
Structure:
Type II transmembrane C-type lectin, 30 kD.
Distribution:
NK cells, subset of T cells, dendritic cells, activated monocytes.
Function:
NKR-P1a is a NK cell-activating receptor; NKR-P1b is a NK cell-inhibitory receptor.
Ligand Receptor:
LLT1-ligand lectin like transcript 1; KLR-killer cell lectin like receptor.
Antigen References:
1. Chambers WH, et al. 1989. J. Exp. Med. 169:1373. 2. Brink M, et al. 1990. J. Exp. Med. 171:197. 3. Li J, et al. 2003. Int. Immunol. 15:411.
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-rat CD161
Lewis rat splenocytes were stained with CD161 (clone 3.2.3) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
PE anti-rat CD161
Lewis rat splenocytes were stained with CD161 (clone 3.2.3) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
APC anti-rat CD161
Lewis rat splenocytes were stained with CD161 (clone 3.2.3) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
