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The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Concentration:
0.2 mg/ml
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
C57BL/6 splenocytes stained with 29-2L17 APC and CD45R/B220 (RA3-6B2) PE
C57BL/6 splenocytes stained with Armenian Hamster IgG isotype control APC and CD45R/B220 (RA3-6B2) PE
CCR6 is a G-protein linked chemokine receptor which binds the chemokine CCL20/MIP-3a. It is expressed on B lymphocytes and certain subsets of dendritic cells and T cells. CCR6 in reported to be involved in mucosal immune response and lymphocyte migration and homeostasis.
Other Names:
CD196, BN-1, CKR-L3, DRY6, KY411, STRL22
Structure:
G-protein linked, seven transmembrane, domain-spanning chemokine receptor. 367 amino acids long and about 75% homology with human CCR6.
Distribution:
Expressed on spleen B cells, immature splenic dendritic cells in Peyer’s patches, and some T cell subset.
Function:
Important in regulating mucosal immune response
Ligand Receptor:
CCL20/MIP-3a
Antigen References:
1. Rossi D, et al. 1997. J. Immunol. 158:1033. 2. Lukacs N, et al. 2001. J. Exp. Med. 194:551. 3. Cook DN, et al. 2000. Immunity 12:495
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-mouse CD196 (CCR6)
C57BL/6 splenocytes stained with purified 29-2L17, followed by biotinylated anti-Armenian hamster IgG and Sav-PE
PE anti-mouse CD196 (CCR6)
C57BL/6 splenocytes stained RA3-6B2 (B220) FITC and 29-2L17 PE
Alexa Fluor® 647 anti-mouse CD196 (CCR6)
C57BL/6 splenocytes stained with RA3-6B2 (B220) PE and 29-2L17 Alexa Flour® 647
PerCP/Cy5.5 anti-mouse CD196 (CCR6)
C57BL/6 splenocytes stained with 29-2L17 PerCP/Cy5.5 and CD45R/B220 (RA3-6B2) APC
C57BL/6 splenocytes stained with Armenian Hamster IgG isotype PerCP/Cy5.5 and CD45R/B220 (RA3-6B2) APC
APC anti-mouse CD196 (CCR6)
C57BL/6 splenocytes stained with 29-2L17 APC and CD45R/B220 (RA3-6B2) PE
C57BL/6 splenocytes stained with Armenian Hamster IgG isotype control APC and CD45R/B220 (RA3-6B2) PE
PE/Cy7 anti-mouse CD196 (CCR6)
C57BL/6 mouse splenocytes stained with 29-2L17 PE/Cy7 and CD45R/B220 (RA3-6B2) APC
C57BL/6 mouse splenocytes stained with rat IgG2a PE/Cy7 isotype and CD45R/B220 (RA3-6B2) APC
Brilliant Violet 421™ anti-mouse CD196 (CCR6)
C57BL/6 mouse splenocytes were stained with CD45R/B220 FITC and CCR6 (clone 29-2L17) Brilliant Violet 421™ (top) or Armenian hamster IgG Brilliant Violet 421™ isotype control (bottom).
