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The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Concentration:
0.2 mg/ml
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application References:
1. Yoshinaga K, et al. 1991. Development. 113:689 2. Broudy VC, et al. 1996. Blood 88:75 3. Arnold IC, et al. 2011. J. Immunol. 186;6165. PubMed. 4. Hitzler I, et al. 2012. J. Immunol. 188:3594. PubMed.
C57BL/6 bone marrow cells stained with ACK2 APC and CD11b (M1/70) FITC
C57BL/6 bone marrow cells stained with rat IgG2b APC isotype control and CD11b (M1/70) FITC
CD117 is a 145 kD immunoglobulin superfamily member, also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with it's ligand is critical for the development of hematopoietic stem cells. ACK2 has been reported to block c-Kit function.
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
PE/Cy5 anti-mouse CD117 (c-kit)
Bone marrow cells from C57BL/6 mice stained with ACK2 PE/Cy5 and CD11b (M1/70) PE
Bone marrow cells from C57BL/6 mice stained with rat IgG2b PE/Cy5 isotype control and CD11b (M1/70) PE
Purified anti-mouse CD117 (c-kit)
C57BL/6 mouse bone marrow cells stained with ACK2 PE and CD11b (M1/70) FITC
PE anti-mouse CD117 (c-kit)
C57BL/6 mouse bone marrow cells stained with ACK2 PE and CD11b (M1/70) FITC
APC anti-mouse CD117 (c-kit)
C57BL/6 bone marrow cells stained with ACK2 APC and CD11b (M1/70) FITC
C57BL/6 bone marrow cells stained with rat IgG2b APC isotype control and CD11b (M1/70) FITC
PE/Cy7 anti-mouse CD117 (c-kit)
Bone marrow cells from C57BL/6 mice stained with ACK2 PE/Cy7 and CD11b (M1/70) APC
Bone marrow cells from C57BL/6 mice stained with rat IgG2b PE/Cy7 isotype control and CD11b (M1/70) APC
