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The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 µl to 5 µl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 µl staining volume or per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
COA:
Human lymphoma cell line, SR, stained with MHJ2-523 APC
The binding of Notch ligands with their receptors results in the proteolysis of Notch and movement of intracellular portion of Notch into the nucleus. This translocation triggers a series of signaling process. The Notch receptors and their ligands are highly conserved signaling molecules throughout development. They regulate cell fate decision for various cell developments, including myogenesis, neurogenesis, and lymphocyte development. There is growing evidence that signals transmitted through different Notch ligands can differentially affect target cells. The Jagged-2 is one of the several Notch ligands identified. It is a single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL (Delta-Serrate-Lag-2) domain, followed by a tandem array of EGF-like repeats (ELRs) and cysteine-rich domain (CRD). Jagged 2 is expressed on lymphoma cells and some other tumor cells. Jagged-2 is reported to be essential for the regulation of spermatogenesis. Notch1/Jagged-2 signaling system plays an important role for male germ cells to differentiate, T cells and B cells to differentiate.
Other Names:
Jag2, Jagged-2
Structure:
A single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL domain, followed by a tandem array of EGF-like repeats (ELRs) and cysteine-rich domain (CRD).
Distribution:
Expressed on lymphoma cells and some other tumor cells.
Function:
Regulate cell fate decision for various cell developments, including myogenesis, neurogenesis, and lymphocyte development.
Ligand Receptor:
Notch molecules
Antigen References:
1. Moriyama Y, et al. 2008. Int J. Immunol. 20:763. 2. Ehebauer MT, et al. 2006. Biochem J 392:13. 3. Shimizu K, et al. 2000. Mol Cell Biology 20:18. 4. Hellstrom M, et al. 2007. Nature 445:776. 5. Luo B, et al. 1997. Mol Cell Biol. 17:6057. 6. Stanley P, et al. 2009. Immunol. Rev. 230(1):201.
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human Jagged 2
Human lymphoma cell line SR stained with MHJ2-523 PE
PE anti-human Jagged 2
Human lymphoma cell line SR stained with MHJ2-523 PE
APC anti-human Jagged 2
Human lymphoma cell line, SR, stained with MHJ2-523 APC
