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The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 µl to 5 µl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 µl staining volume or per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
COA:
Application Notes:
Additional reported (for the relevant formats) applications include: Western blotting.
Application References:
1. Knapp W. 1989. Leucocyte Typing IV. Oxford University Press New York. 2. Barclay N, et al. 1997. The Leucocyte Antigen Facts Book. Academic Press Inc. San Diego. 3. Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. 4. Denny MF, et al. 2010. J. Immunol. 184:3284. PubMed 5. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
Nalm-6 cell line stained with purified HI10a and detected with anti-mouse IgGs-FITC
CD10 is a 100 kD neutral endopeptidase and a member of the metalloprotease family. It is a type II transmembrane protein also known as common acute lymphoblastic leukemia antigen (CALLA), enkephalinase, and neprilysin. CD10 is expressed on B cell precursors, T cell precursors, and neutrophils. CD10 is involved in B cell development and has been shown to bind opioid enkephalins, bradykinin, angiotensins I and II, and other biologically active peptides.
Other Names:
Common acute lymphoblastic leukemia antigen (CALLA), Enkephalinase, Neutral endopeptidase, Neprilysin
Structure:
Type II transmembrane metalloprotease family, 100 kD
Distribution:
B cell precursors, T cell precursors, neutrophils
Function:
Zinc-binding metalloproteinase, B cell development
Ligand Receptor:
Biologically active peptides including opioid enkephalins, bradykinin, angiotensions I & II
Antigen References:
1. Shipp M, et al. 1993. Blood 82:1052. 2. Lu B, et al. 1995. J. Exp. Med. 181:2271.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human CD10
Nalm-6 cell line stained with purified HI10a and detected with anti-mouse IgGs-FITC
PE anti-human CD10
Human pre- B cell line REH stained with HI10a PE
PE/Cy5 anti-human CD10
Human pre- B cell line REH stained with HI10a PE/Cy5
FITC anti-human CD10
Human pre-B cell line REH stained with HI10a FITC
APC anti-human CD10
Nalm-6 cell line stained with purified HI10a and detected with anti-mouse IgGs-FITC
APC/Cy7 anti-human CD10
Human pre- B cell line REH stained with HI10a APC/Cy7
PE/Cy7 anti-human CD10
Human peripheral blood granulocytes stained with HI10a PE/Cy7
PerCP/Cy5.5 anti-human CD10
Human pre-B cell line, Nalm-6, stained with HI10a PerCP/Cy5.5
Brilliant Violet 421™ anti-human CD10
Human pre-B cell line REH was stained with CD10 (clone HI10a) Brilliant Violet 421™ (filled histogram) or mouse IgG1, κ Brilliant Violet 421™ isotype control (open histogram).
