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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 µl per million cells or 5 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm. ** Alexa Fluor® 647 is a registered trademark of Molecular Probes, Inc. Alexa Fluor® 647 dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents.
This product is manufactured and sold under a license and covered by a number of issued patents. Users who intend to file a patent relating to the use of this product, or who intend to develop therapeutic use of this antibody, are required to report to BioLegend in advance.
CD317, also known as BST2, Tetherin, and HM1.24, is a type II transmembrane GPI-protein with a molecular weight of about 29-33 kD. It is an interferon-induced protein expressed on dendritic cells, plasma cells, B lymphoblast cells, monocytes, granulocytes, T cells, NK cells, stromal cells, and some non-hematopoietic cells. BST2 inhibits cytokine production through interaction with ILT7 (CD85g). It is also involved in the regulation of B cell growth. More importantly, BST2 has been found to restrict the release of a number of viruses from infected cells, including all tested retroviruses (such as HIV-1) and some arenaviruses and filoviruses. In HIV-1 studies, it has been reported that BST2 retains the nascent virons on the surface of infected cells by incorporation of the protein into HIV-1 particles. HIV-1 Vpu is able to induce BST2 degradation.
BST2, Tetherin, HM1.24, Bone marrow stromal antigen 2
Type II transmembrane, GPI-anchored protein, 29-33 kD
Dendritic cells, plasma cells, B lymphoblast cells, monocytes, granulocytes, T cells, NK cells, stromal cells
Regulate B cell growth, inhibit cytokine production, retain progeny virons on the surface of infected cells
1. Sugamata OT, et al. 1999. Biochem. Bioph. Res. Co. 258:583. 2. Neil SJ, et al. 2008. Nature 451:425. 3. Fitzpatrick K, et al. 2010. PLoS Pathog. 6:e1000701. 4. Azuma KS, et al. 2008. Cancer Sci. 99:2461. 5. Cao W, et al. 2009. J. Exp. Med. 206:1603. 6. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers.
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Purified anti-human CD317 (BST2, Tetherin)
Human peripheral blood monocytes stained with purified RS38E conjugated with APC