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The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions. The solution is free of unconjugated Alexa Fluor® 647.
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 µl per million cells or 5 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm. ** Alexa Fluor® is a registered trademark of Molecular Probes, Inc. Alexa Fluor® dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents.
CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in human. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and a non-covalent associated with β2-microglobulin, belonging to Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells with tightly regulated manner. The function of CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule.
Other Names:
R7, M241, BDCA-1
Structure:
43 kD, Ig superfamily, MHC I-like molecule, associate with β2-microglobulin
Distribution:
B cell subset, cortical thymocytes, dendritic cells, and Langerhans cells
Function:
Present lipid antigen to CD1c-restricted T cells
Ligand Receptor:
CD1c-restricted TCR
Antigen References:
1. Fainboim LM and del C. Salamone. 2002. J. Biol. Reg. Homeos. Ag. 16:125. 2. M. del Salamone C, et al. 2001. J. Leukocyte Biol. 70:567. 3. Zola H, et al. Eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. P42.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
PerCP anti-human CD1c
Human peripheral blood lymphocytes stained with L161 PerCP
Purified anti-human CD1c
Human peripheral blood lymphocytes stained with purified L161, followed by anti-mouse IgG FITC
Biotin anti-human CD1c
Human peripheral blood lymphocytes stained with biotinylated L161, followed by Sav-PE
PE anti-human CD1c
Human peripheral blood lymphocytes stained with L161 PE
Pacific Blue™ anti-human CD1c
Human T lymphoblastic leukemia cell line, Molt-4, stained with L161 Pacific Blue™
Alexa Fluor® 647 anti-human CD1c
Human T lymphoblastic leukemia cell line, Molt-4, stained with L161 Alexa Fluor® 647
PerCP/Cy5.5 anti-human CD1c
Human peripheral blood lymphocytes stained with L161 PerCP/Cy5.5
Brilliant Violet 421™ anti-human CD1c
Human peripheral blood lymphocytes were stained with CD19 APC and CD1c (clone L161) Brilliant Violet 421™ (top) or mouse IgG1 Brilliant Violet 421™ isotype control (bottom).
PE/Cy7 anti-human CD1c
Human T lymphoblastic leukemia cell line Molt-4 stained with L161 PE/Cy7.
FITC anti-human CD1c
Human T lymphoblastic cell line, Molt-4, stained with L161 FITC
APC/Cy7 anti-human CD1c
Human T-lymphoblastic leukemia cell line, MOLT-4, stained with L161 APC/Cy7
APC anti-human CD1c
Human peripheral blood lymphocytes were stained with CD19 FITC and CD1c (clone L161) APC (top) or Mouse IgG1, κ APC isotype control (bottom).
Alexa Fluor® 488 anti-human CD1c
Human peripheral blood lymphocytes were stained with CD19 APC and CD1c (clone L161) Alexa Fluor® 488 (top) or Mouse IgG1, κ Alexa Fluor® 488 isotype control (bottom).
