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The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions. The solution is free of unconjugated Alexa Fluor® 647.
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 µl per million cells or 5 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm. ** Alexa Fluor® is a registered trademark of Molecular Probes, Inc. Alexa Fluor® dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents.
CCR1 is a chemokine receptor that binds to multiple proinflammatory chemokines. CCR1 is expressed by monocytes/macrophages (≈87% of the peripheral blood), natural killer cells, T cells, DC, monocytes, basophils, eosinophils, osteoclasts, platelets, bone marrow stromal cells, human airway smooth muscle cells (ASMC), and increases in allograft recipients in peripheral blood before rejection (1-3). CCR1 plays a key role in T cell-mediated liver diseases, animal models of pulmonary fibrosis, and might be involved in asthma (1, 4). In addition, CCR1 and CCL23 promoted the chemotactic migration and differentiation of endothelial cells, and neovascularization in the chick chorioallantoic membrane (5).
Other Names:
CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1
Structure:
GPCR, Seven transmembrane receptor
Distribution:
T lymphocytes, NK, DC, monocytes, basophils, eosinophils, osteoclasts, platelets, and human airway smooth muscle cells (ASMC).
Function:
CCR1 is involved in leukocyte migration, endothelial cells differentiation and angiogenesis. CCR1 is induced by TNF-α and IFN-γ in human airway smooth muscle cells (ASMC).
Ligand Receptor:
CCL3, CC3L1, CCl5, CCL7, CCL8, CCL13,CCL14,CCL14,CCL15,CCL16, and CCL23
Antigen References:
1) Joubert P, et al.J. Immunol. 180:1268-1275 2008. 2) Clemetson KJ, et al.Blood 96:4046-4054 2000. 3) Mayer V, et al.NDT 22:1720-1729 2007. 4) Ajuebor NM, et al.Eur. J. Immunol. 34(10):2907-2918 2004. 5) Hwang J, et al.Cytokine 30:254-263 2005.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
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Alexa Fluor® 647 anti-human CD191 (CCR1)
Human peripheral blood monocytes stained with TG4/CCR1 Alexa Fluor® 647
