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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells or 5 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm. ** Alexa Fluor® is a registered trademark of Molecular Probes, Inc. Alexa Fluor® dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents.
CD146 is a 118 kD integral transmembrane glycoprotein also known as MUC18, S-Endo, MCAM, and Mel-CAM (melanoma cell adhesion molecule). It belongs to the immunoglobulin superfamily. CD146 is expressed on melanoma cells, epithelial cells, endothelial cells, fibroblasts, activated T cells, multipotent mesenchymal stromal cells, and activated keratinocytes. CD146 mediates heterophilic cell adhesion and regulates monocyte transendothelial migration. The ligand of CD146 remains to be identified.
1. Pickl WF, et al. 1997. J. Immunol. 158:2107 2. Weninger W, et al. 2000. J. Invest. Dermatol. 115:219 3. Sorrentino A, et al. 2008. Exp. Hematol. 36:1035 4. Bardin N, et al. 2009. Arterioscler. Thromb. Vasc. Biol. 29:746
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Purified anti-human CD146 (MUC18, Mel-CAM)
Human cervical cancer cell line, Hela, stained with purified SHM-57 conjugated with PE
PE anti-human CD146 (MUC18, Mel-CAM)
Human cervical cancer cell line, Hela, stained with SHM-57 PE