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Purified anti-mouse CD371 (CLEC12A) Antibody
Cat. # Size Price  

143401 25 µg $85.00
    
143402 100 µg $185.00
    
Product Details

Clone: 5D3/CLEC12A (See other available formats)
Isotype: Rat IgG2a, κ
Isotype Control:Purified Rat IgG2a, κ Isotype Ctrl
Reactivity: Mouse
Immunogen: CHO expressing mouse CLEC12A
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.





 


Antigen Details

Description: CD371 (CLEC12A), also known as DCAL-2, MICL or CLL-1, is a 30 kD type II transmembrane protein with extracellular C-type lectin domains, belonging to the C-type lectin family.  Its cytoplasmic ITIM motif modulates signaling cascades and is involved in phosphorylation of tyrosine residues in MAP kinases. Mouse CLEC12A is expressed on CD8+ dendritic cells (DCs), a proportion of CD8- dendritc cells, plasmacytoid DCs, monoctyes, macrophages, granulocytes, and B cells.
Other Names: CLL1, MICL, CLL-1, DCAL-2, C-type lectin domain family 12 member A, CD371
Structure: Type II C-type lectin family member, 265 aa, 30.7 kD
Distribution: CD8+ dendritic cells (DCs), a proportion of CD8- dendritic cells, plasmacytoid DCs, monocytes, macrophages, granulocytes, B cells
Function: Negative regulator of granuocyte and monocyte function
Interaction: PTPN6 and PTPN11
Antigen
References:
1. Lahoud MH, et al. 2009. J. Immunol. 182:7587.
2. Chen CH, et al. 2006. Blood 107:1459.
3. Marshall AS, et al. 2004. J. Biol. Chem. 279:14792.
GeneID: 232413
UniProt: View information about CD371 on UniProt.org
Keywords: Purified anti-mouse CD371 (CLEC12A), 5D3/CLEC12A, Purified, CLL1, MICL, CLL-1, DCAL-2, C-type lectin domain family 12 member A, CD371, Mouse, Flow Cytometry, Immunology, Antibodies
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Cell Surface Immunofluorescence Staining Protocol

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

Version: 3 Revision Date: 2015-01-22
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