Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
CD371 (CLEC12A), also known as DCAL-2, MICL or CLL-1, is a 30 kD type II transmembrane protein with extracellular C-type lectin domains, belonging to the C-type lectin family. Its cytoplasmic ITIM motif modulates signaling cascades and is involved in phosphorylation of tyrosine residues in MAP kinases. Mouse CLEC12A is expressed on CD8+ dendritic cells (DCs), a proportion of CD8- dendritc cells, plasmacytoid DCs, monoctyes, macrophages, granulocytes, and B cells.
CLL1, MICL, CLL-1, DCAL-2, C-type lectin domain family 12 member A, CD371
Type II C-type lectin family member, 265 aa, 30.7 kD
CD8+ dendritic cells (DCs), a proportion of CD8- dendritic cells, plasmacytoid DCs, monocytes, macrophages, granulocytes, B cells
Negative regulator of granuocyte and monocyte function
PTPN6 and PTPN11
1. Lahoud MH, et al. 2009. J. Immunol. 182:7587. 2. Chen CH, et al. 2006. Blood 107:1459. 3. Marshall AS, et al. 2004. J. Biol. Chem. 279:14792.
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